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Related Experiment Videos

Alcohol after midazolam sedation: does it really matter?

J L Lichtor1, J Zacny, K Korttila

  • 1Department of Anesthesia, University of Chicago, Illinois 60637.

Anesthesia and Analgesia
|May 1, 1991
PubMed
Summary

Patients receiving midazolam for ambulatory surgery can safely consume alcohol at home hours later. Residual midazolam effects do not significantly interact with or potentiate alcohol

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Area of Science:

  • Pharmacology
  • Anesthesiology
  • Clinical Medicine

Background:

  • Patients undergoing ambulatory surgery may consume alcohol upon returning home.
  • Potential interactions between residual anesthetic effects and alcohol are not well understood.

Purpose of the Study:

  • To investigate if residual intravenous midazolam effects interact with alcohol consumed 4 hours post-injection.
  • To determine if midazolam potentiates alcohol's effects in patients.

Main Methods:

  • Double-blind, randomized, placebo-controlled crossover trial with 16 healthy male volunteers.
  • Subjects received intravenous midazolam or saline, followed by alcohol or placebo beverage 4 hours later.
  • Psychomotor performance and mood were assessed at multiple time points.

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Main Results:

  • Both midazolam and alcohol independently affected psychomotor performance and mood.
  • No significant interactions were observed between midazolam and alcohol.
  • Midazolam did not potentiate alcohol effects, nor did alcohol potentiate midazolam effects.

Conclusions:

  • Residual effects of short-acting benzodiazepines like midazolam likely dissipate before patients arrive home.
  • Alcohol consumption at home is unlikely to be influenced by recent administration of short-acting benzodiazepines used in ambulatory surgery.