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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...

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Updated: Jun 15, 2026

A Treatment Protocol for Achilles Tendinopathy with Extracorporeal Shockwave Therapy
03:50

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Published on: August 2, 2024

Extracorporeal shock wave therapy: current evidence.

Boris A Zelle1, Hans Gollwitzer, Michael Zlowodzki

  • 1Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. zelleba@upmc.edu

Journal of Orthopaedic Trauma
|February 26, 2010
PubMed
Summary
This summary is machine-generated.

Extracorporeal shock wave therapy (ESWT) shows promise in healing bone fractures and nonunions, with a 76% union rate observed in a systematic review. Further research is needed to confirm these findings for fracture healing.

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Area of Science:

  • Orthopedics
  • Biomedical Engineering
  • Regenerative Medicine

Background:

  • Fracture healing complications, including delayed unions and nonunions, present significant clinical challenges.
  • Extracorporeal shock wave therapy (ESWT) is a non-invasive modality with potential regenerative effects.

Purpose of the Study:

  • To review the basic science of ESWT.
  • To systematically review the literature on ESWT for treating fractures and delayed unions/nonunions.

Main Methods:

  • Systematic literature search of PubMed-MEDLINE, Cochrane databases, and meeting abstracts (1966-2008).
  • Inclusion of clinical outcome studies with at least 10 patients, excluding nonunions post-osteotomies or arthrodeses.
  • Extraction of data on sample size, evidence level, union rates, and complications.

Main Results:

  • Analysis of 10 studies involving 924 patients treated with ESWT for delayed union/nonunion.
  • Overall union rate of 76% (95% CI: 73%-79%) across included studies.
  • Significantly higher union rates observed in hypertrophic nonunions compared to atrophic nonunions.

Conclusions:

  • Level 4 evidence suggests ESWT may stimulate bone healing in delayed unions and nonunions.
  • The findings indicate ESWT as a potential therapeutic option for fracture healing.
  • Further high-quality investigations are warranted to solidify the role of ESWT in fracture treatment.