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Inhaled prostacyclin in combination with high-frequency percussive ventilation
Patrick F Allan1, Cindy A Codispoti, Shannon G Womble
1Landstuhl Regional Medical Center, Landstuhl, Germany.
Summary
Inhaled compressed gas cleaner caused severe lung injury. Nebulized prostacyclin during high-frequency percussive ventilation significantly improved oxygenation, enabling patient evacuation.
Area of Science:
- Pulmonary Medicine
- Toxicology
Background:
- Acute respiratory distress syndrome (ARDS) can result from inhaling volatile substances.
- Compressed gas cleaners contain propellants that may cause severe lung injury.
Observation:
- A case of ARDS following inhalation of compressed gas keyboard cleaner is presented.
- Standard ARDS therapies, including mechanical ventilation, were insufficient.
Findings:
- High-frequency percussive ventilation (HFPV) combined with nebulized prostacyclin therapy significantly improved the arterial oxygen tension/fraction of inspired oxygen ratio from 57 to 147 mm Hg.
- This improvement facilitated reduced ventilator support and safe patient transfer.
Implications:
- Nebulized prostacyclin may be a valuable adjunctive therapy for specific ARDS etiologies.
- Further research is needed to confirm the efficacy of inhaled prostacyclin in HFPV for ARDS.
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