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Updated: Jun 15, 2026

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

Published on: May 17, 2021

Awakening dormant haematopoietic stem cells.

Andreas Trumpp¹, Marieke Essers, Anne Wilson

¹Heidelberg Institute for Stem Cell Technology and Experimental Medicine, German Cancer Research Center, Germany. a.trumpp@dkfz.de

Nature Reviews. Immunology

|February 26, 2010

Summary

Dormant hematopoietic stem cells (HSCs) can be activated by specific factors, offering a new strategy. This approach aims to sensitize resistant cancer stem cells to therapies, improving treatment outcomes.

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Area of Science:

Hematology
Stem Cell Biology
Cancer Biology

Background:

Hematopoietic stem cells (HSCs) reside in specialized bone marrow niches.
HSCs exist in dormant and actively self-renewing states, crucial for maintaining blood cell production and long-term potential.
Dormant HSCs are resistant to therapies but can be activated during stress.

Purpose of the Study:

To explore the potential of activating dormant stem cells to overcome therapeutic resistance.
To investigate strategies for targeting resistant leukaemic stem cells.

Main Methods:

Review of factors known to activate dormant stem cells (granulocyte colony-stimulating factor, interferon-alpha, arsenic trioxide).
Proposal of a two-step therapeutic strategy.

Main Results:

Specific factors can efficiently activate dormant stem cells.
Activation of dormant stem cells can overcome resistance to anti-proliferative chemotherapeutics.

Conclusions:

A two-step approach, priming with dormancy activators followed by chemotherapy, could target resistant leukaemic stem cells.
This strategy holds promise for improving cancer treatment by overcoming drug resistance.