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Related Concept Videos

Tight Junctions01:29

Tight Junctions

Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight Junctions
Tight...
Overview of Cell-Cell Junctions01:14

Overview of Cell-Cell Junctions

The complex three-dimensional arrangement of cells in any multicellular organism is defined and maintained by interactions of cells with each other and the extracellular matrix. Cell-cell junctions are specialized structures where the multi-protein complexes on one cell interact with the multi-protein complexes on another  cell. These cell junctions are classified  into three main types based on their function — occluding, anchoring, and gap junctions.
Occluding or Tight Junctions
Tight...
Classification of Epithelial Tissues: Simple Epithelium01:30

Classification of Epithelial Tissues: Simple Epithelium

Simple epithelium consists of a single layer of cells that lines body cavities and blood vessels. The shape of the cells in the epithelium reflects the function of the tissue. Cells in simple squamous epithelium appear as thin scales with flat, elliptical nuclei that mirror the form of the cell.
Because of the thinness of the cells, simple squamous epithelium is present where the rapid passage of chemical compounds is observed. For example, the endothelium that lines the capillaries and vessels...
Salivary Glands and Saliva01:23

Salivary Glands and Saliva

The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
Classification of Epithelial Tissues: Glandular Epithelium01:20

Classification of Epithelial Tissues: Glandular Epithelium

The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...

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Related Experiment Video

Updated: Jun 15, 2026

In Vivo Vascular Permeability Detection in Mouse Submandibular Gland
07:10

In Vivo Vascular Permeability Detection in Mouse Submandibular Gland

Published on: August 4, 2022

Tight junctions in salivary epithelium.

Olga J Baker1

  • 1Department of Oral Biology, University at Buffalo, State University of New York, Buffalo, NY 14214-30932, USA. olgabake@buffalo.edu

Journal of Biomedicine & Biotechnology
|February 26, 2010
PubMed
Summary

Tight junctions (TJs) are crucial for epithelial barriers, but their role in salivary glands is unclear. This review explores TJ regulatory proteins potentially impacting salivary gland epithelial cell function.

Area of Science:

  • Cell Biology
  • Epithelial Biology
  • Physiology

Background:

  • Epithelial cell tight junctions (TJs) form a belt-like structure crucial for tissue barriers and selective transport.
  • While TJs are well-studied in intestines, kidneys, and airways, their function in salivary gland epithelium remains poorly understood.
  • TJ structure and function are dynamic, varying across tissues and species, and are influenced by regulatory proteins.

Purpose of the Study:

  • To review current data on TJ regulatory components.
  • To analyze the potential impact of these components on salivary gland epithelial cell function.
  • To highlight the knowledge gap regarding TJ interactions in salivary glands.

Main Methods:

  • Literature review of existing studies on tight junctions.

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Interrogating Cell-Cell Interactions in the Salivary Gland via Ex Vivo Live Cell Imaging
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Isolation of Salivary Epithelial Cells from Human Salivary Glands for In Vitro Growth as Salispheres or Monolayers
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  • Analysis of TJ regulatory proteins and their known functions.
  • Synthesis of data to infer potential roles in salivary gland epithelium.

    • Main Results:

    • Tight junctions are dynamic structures essential for epithelial barrier integrity.
    • Specific TJ protein interactions dictate tissue-specific functions.
    • The functional significance and regulatory mechanisms of TJs in salivary glands are largely uncharacterized.

    Conclusions:

    • Further research is needed to elucidate the specific roles of TJ regulatory proteins in salivary gland epithelium.
    • Understanding these interactions could reveal novel insights into salivary gland physiology and pathology.
    • This review provides a foundation for future investigations into salivary gland TJ biology.