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Related Concept Videos

Additional Subnuclear Structures02:10

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
The Nucleolus02:55

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
The Nucleolus02:55

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
The Nucleus01:32

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
The Nucleus01:25

The Nucleus

The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...

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Related Experiment Video

Updated: Jun 15, 2026

Nitrogen Cavitation and Differential Centrifugation Allows for Monitoring the Distribution of Peripheral Membrane Proteins in Cultured Cells
08:24

Nitrogen Cavitation and Differential Centrifugation Allows for Monitoring the Distribution of Peripheral Membrane Proteins in Cultured Cells

Published on: August 18, 2017

The perinucleolar compartment.

Callie Pollock1, Sui Huang

  • 1Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.

Cold Spring Harbor Perspectives in Biology
|February 26, 2010
PubMed
Summary
This summary is machine-generated.

The perinucleolar compartment (PNC), rich in RNA-binding proteins, is crucial for cancer progression and metastasis. Its stability depends on pol III transcription, highlighting its potential as a cancer biomarker.

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Last Updated: Jun 15, 2026

Nitrogen Cavitation and Differential Centrifugation Allows for Monitoring the Distribution of Peripheral Membrane Proteins in Cultured Cells
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Published on: August 18, 2017

Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae
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Assessment of Submitochondrial Protein Localization in Budding Yeast Saccharomyces cerevisiae

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • The perinucleolar compartment (PNC) is a distinct subnuclear structure located adjacent to the nucleolus.
  • It is dynamically composed of RNA-binding proteins and RNA polymerase III (pol III) transcribed RNAs.
  • PNC structural integrity is linked to ongoing pol III transcription and specific protein factors.

Purpose of the Study:

  • To summarize the current knowledge on the structure and function of the PNC.
  • To emphasize the association between the PNC and malignant phenotypes.
  • To explore the PNC's potential as a cancer biomarker.

Main Methods:

  • Literature review and synthesis of existing research on the PNC.
  • Analysis of studies investigating PNC composition and stability.
  • Examination of data linking PNC presence and characteristics to cancer malignancy and metastasis.

Main Results:

  • The PNC is a dynamic entity dependent on pol III transcription for its stability.
  • PNC presence and characteristics correlate positively with cancer malignancy and metastatic potential in vitro and in vivo.
  • Emerging evidence suggests a link between the PNC and specific genomic loci.

Conclusions:

  • The PNC plays a significant role in cancer biology, particularly in metastasis.
  • Its dependence on pol III transcription and association with malignancy suggest it as a promising cancer marker.
  • Further research into PNC structure and function is essential for understanding its role in oncogenesis.