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Respiratory adenoviral infections in Taiwanese children: a hospital-based study
Wang-Ying Hsieh1, Nan-Chang Chiu, Hsin Chi
1Department of Pediatrics, Tai-Ann Hospital, Taipei, Taiwan.
Insights
Adenovirus serotype 3 was the leading cause of pediatric respiratory infections in autumn and winter 1999-2000. Most affected children were preschoolers, often requiring hospitalization.
Area of Science:
- Pediatric infectious diseases
- Molecular epidemiology
- Virology
Background:
- Adenoviruses are frequent causes of respiratory infections in children.
- Several serotypes are responsible for epidemic respiratory illnesses.
Purpose of the Study:
- To investigate the molecular epidemiology of pediatric adenoviral infections.
- To analyze the clinical features associated with these infections over a one-year period.
Main Methods:
- Collected virus specimens from children with respiratory tract infections between May 1999 and April 2000.
- Confirmed adenovirus presence using direct fluorescent staining.
- Determined viral types via polymerase chain reaction sequencing.
Main Results:
- Adenoviruses were detected in 272 children; 83.5% were 6 years or younger.
- Adenovirus serotype 3 was most common (60.3%), prevalent in autumn/winter 1999-2000.
- Inpatients were younger than outpatients, and serotype 3 was more frequent in inpatients.
Conclusions:
- Adenovirus serotype 3 predominated pediatric respiratory infections during autumn/winter 1999-2000.
- Preschool-aged children were most affected, frequently requiring hospital admission.
- Clinical manifestations showed little variation across different serotypes.
Background And Purpose:
Adenoviruses are a common etiology of respiratory tract infections in children, with several serotypes responsible for most epidemic respiratory infections. This study examined the molecular epidemiology and clinical features of pediatric adenoviral infections in a 1-year period.
Methods:
From May 1999 to April 2000, virus specimens collected from children with respiratory tract infections were identified. The presence of adenovirus was confirmed by direct fluorescent staining, and viral types were determined by polymerase chain reaction sequencing.
Results:
Adenoviruses were identified from 272 children (mean +/- standard deviation age, 48.3 +/- 30.5 months), 227 (83.5%) of whom were aged 6 years or younger. Inpatients were younger than outpatients (44.1 +/- 30.7 months vs 53.0 +/- 29.4 months; p = 0.006). The commonest serotype identified was serotype 3 (164 patients; 60.3%), 73.1% of which were identified between September 1999 and January 2000. Serotype 3 was more common in inpatients (p = 0.015), while serotypes 1, 2, 5, and 6 were more common in outpatients (p = 0.021). Patients with pneumonia were younger than those with other infections (31.8 +/- 20.2 months vs 50.3 +/- 31.0 months; p = 0.001). Most of the children (90.1%) had fever for a mean of 3.80 +/- 2.65 days before seeing a doctor. The clinical manifestations were similar regardless of the serotype.
Conclusions:
Adenovirus serotype 3 caused the most adenovirus infections in autumn and winter of 1999 to 2000. The children were mostly preschool age and required hospital admission.
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