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Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Th17 cells in mucosal immunity and tissue inflammation

Jay K Kolls1

  • 1Department of Genetics, LSU Health Sciences Center, New Orleans, LA 70112, USA. jkolls@lsuhsc.edu

Seminars in Immunopathology
|February 26, 2010
PubMed

T helper type 17 (Th17) cells are a distinct lineage of T cells that produce the effector molecules IL-17, IL-17F, IL-21, and IL-22. Th17 cells have been shown to have critical roles in autoimmunity and tissue inflammation. However, emerging evidence also shows these cells are critical regulators of host immunity against bacterial, fungal, and viral infections at mucosal surfaces. Moreover, these cells can be induced following vaccination and have been shown to be critical for vaccine efficacy against both extracellular and intracellular pathogens. In this issue, we summarize recent progress in our understanding of the function of Th17 cells and where these cells fit in protective immunity and immunopathology.

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