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Published on: March 21, 2017
Stem cell competition for niche occupancy: emerging themes and mechanisms
1National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206, China.
Abstract:
Tissue-specific adult stem cells are responsible for generating a range of various differentiated cells during their life time; these cells are intimately associated with niche for maintenance and function. Recent studies of germline stem cell niches in Drosophila gonad suggest that stem cells within a niche constantly compete with each other for niche occupancy. Competition within a niche occurs between same type of stem cells as well as different types. In both cases, cell adhesion molecules are critical in mediating the competition.
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