Integration of Web 2.0 technologies in the translational research environment

Kristi L Holmes1, Ellen K Dubinsky

  • 1Washington University School of Medicine, Bernard Becker Medical Library, 660 South Euclid, Campus Box 8132, St. Louis, MO 63110, USA. holmeskr@wustl.edu

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Sec61 channel partners for cotranslational translocation
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Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
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Cost Containment
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Translational Regulation

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