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Asphorodin, a potent lipoxygenase inhibitory triterpene diglycoside from Asphodelus tenuifolius

Muhammad Safder¹, Muhammad Imran, Rashad Mehmood

¹International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.

Journal of Asian Natural Products Research

|February 26, 2010

Abstract:

Asphorodin (1), a new diglycoside, has been isolated from the ethyl acetate-soluble fraction of Asphodelus tenuifolius. It showed significant inhibitory activity against the enzyme lipoxygenase in a concentration-dependent manner. The Lineweaver-Burk and Dixon plots indicated that the nature of inhibition was non-competitive.

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