Related Experiment Video
Updated: Jun 15, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
Synthesis and evaluation of solanesol derivatives as novel potent synergistic agents
Jian-Hong Wang1, Rui-Hong Gao, Ying Gan
1Key Laboratory of Natural Medicinal and Immunotechnology, Henan University, Kaifeng, China.
Abstract:
Novel solanesylpiperazinotriamines as well as their N-aryl-substituted analogs were synthesized starting from solanesol through a multistep procedure. Their structures were confirmed by IR, (1)H NMR, MS, and elemental analysis. The preliminary results indicated that these novel derivatives were preferentially toxic against tumor cells, and at non-cytotoxic concentration, the synergistic effect of solanesyltriamines (3a and 3c) was even superior to that of N,N'-bis(3,4-dimethoxybenzyl)-N-solanesylethylenediamine. Interestingly, the cytotoxicity of solanesylpiperazinotriamine derivatives was markedly enhanced when conjugating with aryl pharmacophores (7-9).
Related Concept Videos
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Preparation and Reactions of Sulfides
Combined Effects of Drugs: Antagonism
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...
Agonism and Antagonism: Quantification
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
Solvents
A...
Bioavailability Enhancement: Drug Solubility Enhancement

