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Related Experiment Video

Updated: Jun 15, 2026

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

Two new steroidal glucosides from Tribulus terrestris L.

Ya-Juan Xu¹, Tun-Hai Xu, Yue Liu

¹Institute of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine and Material Medica of Jilin Province, Changchun, China.

Journal of Asian Natural Products Research

|February 26, 2010

Summary

Researchers discovered two novel furostanol saponins, tribufurosides D and E, from Tribulus terrestris fruits. Their structures were elucidated using advanced spectroscopic techniques, expanding knowledge of plant-derived compounds.

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Last Updated: Jun 15, 2026

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Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Published on: March 3, 2023

Area of Science:

Natural Product Chemistry
Phytochemistry
Organic Chemistry

Background:

Tribulus terrestris L. is a plant known for its traditional medicinal uses.
Furostanol saponins are a class of bioactive compounds found in various plants.
Understanding the chemical constituents of medicinal plants is crucial for pharmacological research.

Purpose of the Study:

To isolate and characterize new furostanol saponins from the fruits of Tribulus terrestris L.
To elucidate the chemical structures of these novel compounds using spectroscopic methods.

Main Methods:

Isolation of compounds using chromatographic techniques.
Structure elucidation through Infrared (IR) spectroscopy, Mass Spectrometry (MS), and Nuclear Magnetic Resonance (NMR) spectroscopy (1D and 2D).

Main Results:

Two new furostanol saponins, designated tribufurosides D (1) and E (2), were successfully isolated.
The detailed chemical structures of tribufurosides D and E were established based on comprehensive spectral data.
Compound 1 was identified as 26-O-beta-d-glucopyranosyl-(25S)-5alpha-furost-12-one-2alpha,3beta,22alpha,26-tetraol-3-O-beta-d-glucopyranosyl-(1 --> 4)-beta-d-galactopyranoside.
Compound 2 was identified as 26-O-beta-d-glucopyranosyl-(25R)-5alpha-furost-12-one-2alpha,3beta,22alpha,26-tetraol-3-O-beta-d-glucopyranosyl-(1 --> 4)-beta-d-galactopyranoside.

Conclusions:

The study successfully identified and characterized two previously unknown furostanol saponins from Tribulus terrestris.
The findings contribute to the phytochemical knowledge of Tribulus terrestris and the broader class of furostanol saponins.
This research provides a foundation for further investigation into the potential biological activities of these novel compounds.