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Sample size for testing difference between two proportions for the bilateral-sample design
Shi-Fang Qiu1, Nian-Sheng Tang, Man-Lai Tang
1Department of Statistics, Yunnan University, Kunming, People's Republic of China.
Abstract:
In this article, we consider approximate sample size formulas for testing difference between two proportions for bilateral studies with binary outcomes. Sample size formulas are derived to achieve a prespecified power of a statistical test at a prechosen significance level. Four statistical tests are considered. Simulation studies are conducted to investigate the accuracy of various formulas. In general, the sample size formula for Rosner's statistic based on the dependence assumption is highly recommended in the sense that its actual power is satisfactorily close to the desired power level. An example from an otolaryngological study is used to demonstrate the proposed methodologies.
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