Related Experiment Video
Updated: Jun 15, 2026

Synthetic Condensates and Cell-Like Architectures from Amphiphilic DNA Nanostructures
Published on: May 31, 2024
Synthesis of novel 5'-uridine-head amphiphiles as model for DNA molecular recognition
Matteo Tiecco1, Pietro Di Profio, Raimondo Germani
1CEMIN-Excellence Centre on Innovative Nanostructured Materials, Department of Chemistry, University of Perugia, Perugia, Italy.
Abstract:
Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed as DNA transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization that occurs when uridine is functionalized in this position without using protecting groups in the uracil.
Related Concept Videos
DNA Base Pairing
Nucleic Acid Structure
DNA Structure
DNA has a double-helix structure. The...
The DNA Helix
The DNA Helix
Maxam-Gilbert Sequencing
Challenges of the Maxam-Gilbert Method
The...
Nucleic acids
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes, the...

