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Updated: Jun 15, 2026

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
Published on: July 25, 2013
[The evolutionary optimality principle as a tool to model structured biological systems]
Abstract:
Suggested are some ways to use the theory of evolutionary optimality for modelling of structured biological communities. The functionals to be optimized are constructed for communities with age, with space, and with age-space continuous structures. The functionals are calculated on the basis of information available on steady-state distributions and are optimized over parameters essential from the viewpoint of evolutionary selection. Found as a result, the optimal values are used to identify the parameters. As a practical application, the central result of correlation adaptometry theory is formulated and an example is given for how it can be used to evaluate reactions of herbaceous species to stressful loads.
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