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Updated: Jun 15, 2026
09:20
Intradermal Inoculation of Mycobacterium avium in the Mouse Ear
Published on: July 3, 2025
[Two cases of Mycobacterium avium complex pleuritis].
Takashi Ishiguro1, Noboru Takayanagi, Hiroo Saito
1Respiratory Medicine, Saitama Cardiovascular and Respiratory Center.
Summary
Mycobacterium avium complex (MAC) pleuritis is rare. This report details two cases, one in a woman with rheumatoid arthritis and another in a man with nephritic syndrome, both treated successfully with antibiotics and supportive care.
Area of Science:
- Infectious Diseases
- Pulmonology
- Rheumatology
Background:
- Mycobacterium avium complex (MAC) pleuritis is an uncommon infection.
- Its rarity makes understanding its characteristics and prognosis challenging.
Observation:
- Two cases of MAC pleuritis are presented: a 68-year-old woman with rheumatoid arthritis and a 71-year-old man with nephritic syndrome.
- Both patients were immunocompromised due to steroid treatment and presented with dyspnea.
Findings:
- The first patient improved with chest tube insertion and a multi-drug regimen including rifampicin, ethambutol, clarithromycin, and streptomycin.
- The second patient improved with therapeutic thoracentesis and clarithromycin.
Implications:
- These cases contribute to the limited literature on MAC pleuritis, highlighting potential treatment approaches.
- Early diagnosis and appropriate antimicrobial therapy appear crucial for favorable outcomes in this rare condition.
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