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Updated: Jun 15, 2026

Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
Development of new fluorescent xanthines as kinase inhibitors
Donghee Kim1, Hwiseok Jun, Hyunseung Lee
1Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Korea.
Abstract:
An efficient and versatile synthetic approach for the preparation of highly substituted xanthine derivatives has been developed by a combination of direct N7- and C8-arylation. With this method, diverse xanthine analogues were prepared and potent kinase inhibitors could be identified. For example, compound 8a inhibits PI3Ks and proliferation in T47D tumor cells. In addition, these xanthine-based kinase inhibitors exhibited significant fluorescence emission in a concentration-dependent response.
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