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Updated: Jun 15, 2026
Detecting Behavioral Deficits in Rats After Traumatic Brain Injury
Published on: January 30, 2018
Predictive utility of weekly post-traumatic amnesia assessments after brain injury: A multicentre analysis
Allen W Brown1, James F Malec, Jay Mandrekar
1Mayo Clinic, Rochester, MN, USA. brown.allen@mayo.edu
Primary Objective:
To consider the duration of post-traumatic amnesia (PTA) as a single predictor variable to determine whether categories of PTA duration exist that predict 1-year outcomes after traumatic brain injury (TBI).
Research Design:
Using the TBI Model System database (n = 5250), the duration of PTA that predicts 1-year outcomes was calculated. Logistic regression was used to determine whether a single predictive threshold value existed. Classification and regression tree analysis then determined whether multiple threshold values existed. The area under the ROC curve and percentage correct classification were also calculated to discriminate classification accuracy and choose the best predictive thresholds.
Results:
A single threshold value of PTA days was identified for all variables. At 1 year, PTA that extended into week 7 after injury predicted total FIM and FIM sub-scales. One-year employment and global outcomes were predicted by PTA extending into week 4 after injury. Independent living was predicted by PTA extending into the 8th week after injury.
Conclusion:
After moderate-to-severe TBI, determining the presence of PTA at weekly intervals can efficiently determine injury severity while providing meaningful precision when used in research and clinical outcome prediction.
