Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Total nitrogen content of human duodenal juice before and after intravenous injection of secretin.

Scandinavian journal of gastroenterology·2010
Same author

[The study of gastric secretory function in Norway (a historical review)].

Vestnik Rossiiskoi akademii meditsinskikh nauk·1996
Same author

Effects of the prostaglandin E2 analogue enprostil on the carbon tetrachloride-induced necrosis of liver cells in mice.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·1992
Same author

On minimum requirements in education and training for obtaining a license in gastroenterology.

Scandinavian journal of gastroenterology·1992
Same author

Education and training in gastroenterology--recommendations from the OMGE-Workshops, at the International Congresses of Gastroenterology, Rome, 1988, and at the World Congresses, Sydney, Australia 1990.

Endoscopy·1992
Same author

Education and training in gastroenterology.

The Italian journal of gastroenterology·1992
Same journal

Textbook outcome after esophagectomy in Norway - a national cohort study of low- to medium-volume centers.

Scandinavian journal of gastroenterology·2026
Same journal

Fecal calprotectin concentration in adults with and without <i>Helicobacter pylori</i> infection.

Scandinavian journal of gastroenterology·2026
Same journal

Endoloop-clip closure versus hemoclips for large sigmoid colon perforations: a randomized controlled <i>ex vivo</i> study.

Scandinavian journal of gastroenterology·2026
Same journal

Outcomes associated with secondary spontaneous bacterial peritonitis (SBP) prophylaxis after hospital discharge in a nation-wide Swedish cohort.

Scandinavian journal of gastroenterology·2026
Same journal

Supra-papillary versus trans-papillary stenting for malignant biliary obstruction: an updated meta-analysis of randomized trials.

Scandinavian journal of gastroenterology·2026
Same journal

Acute upper gastrointestinal bleeding: a population-based cohort study from Southern Iceland.

Scandinavian journal of gastroenterology·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2026

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Colchicine effects on the mouse liver.

J Myren1, R Ceballos, G C Luketic

  • 1Division of Gastroenterology, Department of Medicine and Pathology, University of Alabama Medical Center, Birmingham, Alabama, USA.

Scandinavian Journal of Gastroenterology
|February 27, 2010
PubMed
Summary
This summary is machine-generated.

Colchicine rapidly inhibits liver dehydrogenase activity, an effect independent of cell division inhibition. While dose-dependent, repeated small doses of colchicine allowed enzyme activity to normalize without causing liver cell damage.

More Related Videos

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Related Experiment Videos

Last Updated: Jun 15, 2026

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented (CDE) Diet Model of Chronic Liver Injury

Published on: October 21, 2017

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Area of Science:

  • Biochemistry
  • Cell Biology
  • Toxicology

Background:

  • Colchicine is known to inhibit cell division.
  • Previous studies indicated colchicine's effect on intestinal mucosa.

Purpose of the Study:

  • To investigate the immediate impact of colchicine on mouse liver dehydrogenase activity.
  • To determine if this effect is linked to cell division inhibition.
  • To compare the effects of single versus repeated colchicine doses.

Main Methods:

  • Histochemical analysis of mouse liver tissue.
  • Administration of single and repeated doses of colchicine at varying concentrations (0.24 mg/kg and 1.5 mg/kg).
  • Assessment of succinic-, lactic-, glucose-6-phosphate-, NADH-, and NADPH-dehydrogenase activity.

Main Results:

  • A single colchicine dose caused instantaneous and significant inhibition of key liver dehydrogenases.
  • The inhibitory effect was similar to that observed in the intestinal mucosa and not related to cell division.
  • Higher doses and repeated administration led to more pronounced and prolonged enzyme depression, morphological alterations, and mortality.
  • Repeated low doses normalized dehydrogenase activity without observable morphological changes.

Conclusions:

  • Colchicine exerts a direct inhibitory effect on liver dehydrogenase activity.
  • The observed effects are dose-dependent and not a secondary consequence of antimitotic activity.
  • Low-dose colchicine administration can lead to reversible enzyme activity changes, while high or prolonged doses induce significant toxicity.