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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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Related Experiment Video

Updated: Jun 15, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Liver transplantation using elderly donors: a risk factor analysis.

Dae Y Kim1, Jang Moon, Eddie R Island

  • 1Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.

Clinical Transplantation
|February 27, 2010
PubMed
Summary
This summary is machine-generated.

Using elderly deceased donors for liver transplantation (LT) is feasible. Careful patient selection and donor management, particularly blood glucose levels, improve graft survival rates in LT recipients.

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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

Related Experiment Videos

Last Updated: Jun 15, 2026

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
12:49

Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model

Published on: August 17, 2022

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation
08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

Area of Science:

  • Transplantation Medicine
  • Hepatology
  • Geriatric Donor Utilization

Background:

  • Liver transplantation (LT) outcomes are impacted by donor age.
  • Excluding elderly deceased donors increases waiting times and mortality.
  • Utilizing elderly donors requires careful evaluation to optimize graft survival.

Purpose of the Study:

  • To identify factors influencing graft survival in LT using deceased donors aged 65 years and older.
  • To assess the viability of employing elderly donor livers in LT programs.
  • To establish criteria for successful LT with older donor allografts.

Main Methods:

  • Retrospective review of primary LT cases using deceased donor livers from donors aged ≥ 65 years (February 1995 - November 2003).
  • Multivariate analysis to identify unfavorable characteristics associated with graft failure.
  • Evaluation of graft survival rates based on the number of unfavorable characteristics.

Main Results:

  • Four unfavorable characteristics significantly correlated with higher post-transplant graft failure: hepatitis C etiology, Model for End-Stage Liver Disease (MELD) score >20, donor serum glucose >200 mg/dL, and donor surgery time (skin incision to aortic cross-clamp) >40 minutes.
  • Five-year estimated graft survival rates decreased significantly with an increasing number of unfavorable factors (100% for 0 factors to 25.0% for 4 factors).
  • Appropriate patient selection and donor management are crucial for successful outcomes.

Conclusions:

  • Liver transplantation using elderly donor allografts can achieve good graft survival.
  • Key strategies include careful patient selection, managing donor blood glucose, and efficient liver recovery with minimal manipulation.
  • Optimizing the use of elderly donor livers can mitigate waiting list challenges in LT.