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Published on: January 9, 2019
GOLPH2 expression may serve as diagnostic marker in seminomas.
Florian R Fritzsche1, Glen Kristiansen, Marc-Oliver Riener
1Institute of Surgical Pathology, Universitäts Spital Zürich, Zurich, Switzerland. florian.fritzsche@usz.ch
BMC Urology
|February 27, 2010
Summary
Golgi phosphoprotein 2 (GOLPH2) is highly expressed in testicular seminomas and Leydig cell tumors, suggesting its potential as a diagnostic marker for these neoplasms.
Area of Science:
- Oncology
- Molecular Pathology
- Biomarker Discovery
Background:
- Golgi phosphoprotein 2 (GOLPH2) is a novel Golgi membrane protein.
- Upregulation of GOLPH2 has been proposed as a biomarker for hepatocellular and prostate carcinoma.
- Its role in other carcinomas and as a generic marker of malignancy remains undetermined.
Purpose of the Study:
- To evaluate the expression pattern of GOLPH2 in testicular seminomas.
- To determine if GOLPH2 overexpression is specific to malignancy or a general indicator.
- To assess GOLPH2 expression in Leydig cell tumors.
Main Methods:
- Immunohistochemistry was used to assess GOLPH2 protein expression.
- 69 testicular seminomas were analyzed.
- Expression was compared to normal testicular tissue, intratubular germ cell neoplasia, and Leydig cell tumors.
Main Results:
- GOLPH2 was overexpressed in 89.9% of seminomas.
- Non-neoplastic tissue showed weak or negative staining for GOLPH2.
- GOLPH2 was also highly expressed in Leydig cells and Leydig cell tumors.
Conclusions:
- GOLPH2 protein is highly expressed in both seminomas and Leydig cell tumors.
- GOLPH2 shows potential as a novel immunohistochemical marker for testicular neoplasms.
- Further studies on serum GOLPH2 levels and non-seminomatous germ cell tumors are warranted.
