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Related Experiment Video

Updated: Jun 15, 2026

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

Cochlear implantation: an opportunity for drug development.

Hinrich Staecker1, Claude Jolly, Carolyn Garnham

  • 1Department of Otolaryngology Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, KS 66160, USA.

Drug Discovery Today
|February 27, 2010
PubMed
Summary

Local drug treatments for the inner ear are now possible thanks to advancements in cochlear implantation. This approach offers a new way to prevent hearing loss in patients with residual hearing.

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Intracochlear Drug Delivery Using a Catheter and Dexamethasone-Eluting Electrode Preserves Residual Hearing Post-Cochlear Implantation.

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Area of Science:

  • Otolaryngology
  • Pharmacology
  • Biomedical Engineering

Background:

  • Inner ear pharmacology and hearing device development have historically advanced separately.
  • Recent progress in understanding inner ear pathologies has created new opportunities for integrated treatments.
  • Cochlear implantation is increasingly used for individuals with residual hearing who gain limited benefit from hearing aids.

Purpose of the Study:

  • To explore the potential of combining cochlear implantation with local drug delivery for inner ear treatment.
  • To investigate the feasibility of implanting devices into partially deaf inner ears with minimal hearing loss.
  • To leverage advancements in cochlear implant technology for therapeutic interventions.

Main Methods:

  • Review of current advancements in inner ear research and cochlear implant technology.

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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
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A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

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Last Updated: Jun 15, 2026

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
09:06

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
09:18

A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection

Published on: March 8, 2017

  • Analysis of the implications of implanting devices in partially deaf inner ears.
  • Conceptual framework for developing implantable drug delivery systems.

    • Main Results:

    • Cochlear implantation can be performed with minimal hearing loss, even in ears with residual hearing.
    • The integration of devices into the partially deaf inner ear enables localized treatment strategies.
    • This convergence opens avenues for targeted pharmacological interventions.

    Conclusions:

    • The evolution of cochlear implantation provides a unique platform for local drug treatment of the inner ear.
    • This approach holds promise for preventing further hearing degeneration.
    • Future research should focus on developing implantable pharmacologic interventions.