Related Experiment Video
Updated: Jun 15, 2026
Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
Published on: November 11, 2021
[Case report of a 2-year-old child with palpebral rhabdomyosarcoma]
N Bonnin1, H Nezzar, A Viennet
1Service d'ophtalmologie, Hôpital Gabriel Montpied, CHU Clermont-Ferrand, Clermont-Ferrand. nicoasmo@yahoo.fr <nicoasmo@yahoo.fr>
Insights
Early diagnosis of rare levator palpebrae superioris muscle rhabdomyosarcoma in a child improved survival. This rare tumor, presenting as sudden blepharoptosis, was successfully treated with chemotherapy and orbital radiotherapy.
Area of Science:
- Ophthalmology
- Pediatric Oncology
- Pathology
Background:
- Rhabdomyosarcoma is a rare and aggressive tumor.
- Early diagnosis significantly impacts survival and visual outcomes.
- Orbital rhabdomyosarcoma requires prompt identification and management.
Observation:
- A 2-year-old child presented with sudden, isolated blepharoptosis.
- Initial investigations were inconclusive, but a painful, hematoma-associated tumor rapidly developed.
- A CT scan revealed an extra-conal orbital tumor.
Findings:
- Histological examination confirmed embryonic rhabdomyosarcoma.
- The tumor was located in the superior orbit.
- Successful treatment was achieved with a combination of chemotherapy and orbital radiotherapy.
Implications:
- This case highlights the importance of repeated investigations for suspected orbital tumors.
- Prompt and aggressive treatment, including chemotherapy and radiotherapy, can lead to successful outcomes in pediatric orbital rhabdomyosarcoma.
- Effective management strategies are crucial for improving prognosis in rare pediatric cancers.
Abstract:
Rhabdomyosarcoma is an extremely virulent rare tumor whose early diagnosis considerably improves survival and visual prognosis. We report the case of a 2-year-old child with levator palpebrae superioris muscle rhabdomyosarcoma revealed by a sudden and isolated blepharoptosis. Initially, clinical and imaging investigations did not show any abnormality but a painful tumor with some hematoma quickly developed, so the investigations were repeated. The CT-scan showed an extra-conal tumor that had developed at the superior part of the orbit. Histology confirmed the diagnosis of embryonic rhabdomyosarcoma. Because of its results, treatment consisting of chemotherapy associating ifosfamide, vincristine, actinomycin and orbital radiotherapy of 40 Gy with a local addition of 10 Gy were administrated with successful results after a 3-year-follow-up.
Related Concept Videos
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:20The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:03Rous Sarcoma Virus (RSV) and Cancer
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...