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Related Concept Videos

Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...

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Related Experiment Video

Updated: Jun 15, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Sub-clinical left and right ventricular dysfunction in patients with COPD.

Ramsey Sabit1, Charlotte E Bolton, Alan G Fraser

  • 1Department of Respiratory Medicine, Wales Heart Research Institute, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, United Kingdom.

Respiratory Medicine
|February 27, 2010
PubMed
Summary
This summary is machine-generated.

Patients with chronic obstructive pulmonary disease (COPD) exhibit sub-clinical left and right ventricular dysfunction. These cardiac issues are linked to airflow obstruction and arterial stiffness, appearing even in mild COPD.

More Related Videos

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Related Experiment Videos

Last Updated: Jun 15, 2026

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice
08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

Area of Science:

  • Cardiology
  • Pulmonology
  • Echocardiography

Background:

  • Cardiovascular diseases are common in COPD patients, including arterial stiffness, heart failure, and cor pulmonale.
  • Sub-clinical right (RV) and left ventricular (LV) dysfunction are hypothesized in COPD, linked to obstruction severity, arterial stiffness, and inflammation.

Purpose of the Study:

  • To investigate sub-clinical RV and LV dysfunction in COPD patients.
  • To determine the relationship between ventricular dysfunction, airflow obstruction, arterial stiffness, and inflammation.

Main Methods:

  • 36 COPD patients and 14 controls underwent tissue Doppler echocardiography, spirometry, and arterial stiffness measurements (PWV).
  • Systemic inflammatory markers were analyzed via venous sampling.

Main Results:

  • COPD patients showed reduced LV strain/strain rate and prolonged LV IVRT, indicating diastolic dysfunction.
  • RV dysfunction (reduced strain/strain rate) and sub-clinical pulmonary hypertension were observed in COPD patients.
  • Arterial stiffness (PWV) predicted LV diastolic dysfunction, while airflow obstruction (FEV1) predicted RV dysfunction.

Conclusions:

  • COPD patients have sub-clinical LV dysfunction associated with arterial stiffness.
  • COPD patients have sub-clinical RV dysfunction associated with airflow obstruction.
  • Ventricular dysfunction is present even in mild COPD, suggesting early cardiac comorbidities.