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Updated: Jun 15, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

Landscape phage ligands for PC3 prostate carcinoma cells.

P K Jayanna¹, D Bedi, P Deinnocentes

¹Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA.

Protein Engineering, Design & Selection : PEDS

|February 27, 2010

Summary

Researchers used phage display technology to identify novel peptide ligands targeting prostate cancer cells. These phage ligands show promise for developing targeted therapies and diagnostics for prostate carcinoma.

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Area of Science:

Nanobiotechnology
Molecular Biology
Oncology

Background:

Targeting drugs to tumor receptors enhances efficacy.
Phage display is a powerful tool for identifying specific molecular ligands.
Phage nanobiotechnology enables the use of phage particles in nanomedicine.

Purpose of the Study:

To identify phage ligands with specificity for PC3 prostate carcinoma cells.
To explore the potential of these ligands in nanomedicine applications.

Main Methods:

Utilized two landscape phage libraries for ligand selection.
Employed a stringent selection scheme to isolate specific binders.
Validated ligand specificity using target-association assays, microscopy, and flow cytometry.

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Published on: May 15, 2014

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

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Published on: August 29, 2016

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Last Updated: Jun 15, 2026

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells

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Main Results:

Identified three specific phage ligands: DTDSHVNL, DTPYDLTG, and DVVYALSDD.
Demonstrated specificity and selectivity of these ligands for PC3 cells.
Confirmed the utility of phage ligands and coat proteins as navigating modules.

Conclusions:

The identified phage ligands are effective for targeting prostate carcinoma cells.
These ligands can be utilized in developing novel therapeutic and diagnostic nanomedicines for prostate cancer.