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Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
Published on: July 3, 2014
Intracerebral hemorrhage in cocaine users
Sheryl Martin-Schild1, Karen C Albright, Hen Hallevi
1Department of Neurology, Tulane University, New Orleans, LA, USA.
Stroke
|February 27, 2010
Summary
Recent cocaine use significantly increases the risk of intracerebral hemorrhage (ICH), leading to poorer outcomes and higher mortality rates compared to non-cocaine-related ICH.
Area of Science:
- Neurology
- Toxicology
- Public Health
Background:
- Cocaine use is a known risk factor for intracerebral hemorrhage (ICH).
- Limited large-scale studies exist on the characteristics and outcomes of cocaine-associated ICH.
Purpose of the Study:
- To characterize the location, pathology, and outcomes of patients with cocaine-associated ICH.
- To compare cocaine-associated ICH with spontaneous ICH in patients without cocaine use.
Main Methods:
- Retrospective analysis of non-traumatic ICH patients admitted between 2004-2007.
- Comparison of patients with cocaine-positive urine drug screens versus those with cocaine-negative screens.
Main Results:
- Cocaine-associated ICH occurred more frequently in Black patients and was linked to higher blood pressure.
- Patients with cocaine-associated ICH showed a higher incidence of subcortical and intraventricular hemorrhages.
- Cocaine-associated ICH was associated with worse functional outcomes, lower discharge to home/rehab, and a nearly 3-fold increased mortality risk.
Conclusions:
- Cocaine ingestion is linked to ICH with specific characteristics: subcortical location and higher intraventricular hemorrhage risk.
- Cocaine-associated ICH carries a significantly poorer prognosis compared to spontaneous ICH in non-users.
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