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Updated: Jun 15, 2026

Two Peeling Methods for the Isolation of Photoreceptor Cell Compartments in the Mouse Retina for Protein Analysis
Published on: December 7, 2021
Deactivation mechanisms of rod phototransduction: the Cogan lecture
1Department of Ophthalmology and Vision Science and Center for Neuroscience, University of California, Davis, California, USA
Abstract:
The absorption of photons in rods and cones of the retina activate homologous biochemical signaling cascades that lead to the electrical changes that subserve the first steps in vision. Persistent activity of the cascade interferes with the ability of the photoreceptor to signal the absorption of subsequent photons, ultimately limiting the photoreceptor's sensitivity and temporal resolution. This article summarizes recent work on transgenic and knockout mouse rods that has revealed the deactivation mechanisms essential for normal response recovery and how each of these processes contributes to the overall time course of the flash response of rods.
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