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Psoriasis associated with hepatitis C but not with hepatitis B
Arnon D Cohen1, Dahlia Weitzman, Shlomo Birkenfeld
1Clalit Health Services, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Dermatology (Basel, Switzerland)
|February 27, 2010
Summary
Psoriasis is linked to a higher risk of hepatitis C infection, particularly in smokers. This study suggests screening psoriasis patients for hepatitis C, as it was not associated with hepatitis B.
Area of Science:
- Dermatology
- Hepatology
- Epidemiology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Viral hepatitis, including hepatitis B and C, are significant public health concerns.
- Previous research suggests potential links between psoriasis and viral infections.
Purpose of the Study:
- To investigate the association between psoriasis and viral hepatitis (hepatitis B and C).
- To determine if psoriasis prevalence correlates with viral hepatitis in a large patient cohort.
Main Methods:
- A case-control study design was employed.
- 12,502 psoriasis patients were compared with 24,287 age- and sex-matched controls.
- Logistic multivariate models were used to analyze the prevalence of viral hepatitis.
Main Results:
- Psoriasis patients showed a significantly higher prevalence of hepatitis C (1.03%) compared to controls (0.56%; p < 0.001).
- Psoriasis was independently associated with hepatitis C, with a notable interaction with smoking status.
- While hepatitis B prevalence was slightly higher in psoriasis patients, it was not statistically associated in multivariate analysis.
Conclusions:
- The findings support a significant association between psoriasis and hepatitis C, but not hepatitis B.
- Healthcare providers should consider screening psoriasis patients for hepatitis C due to this observed association.
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