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Updated: Jun 15, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
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Published on: August 13, 2019

Androgens and cardiovascular disease.

Bu B Yeap1

  • 1School of Medicine and Pharmacology, University of Western Australia, Perth, Australia. byeap@cyllene.uwa.edu.au

Current Opinion in Endocrinology, Diabetes, and Obesity
|February 27, 2010
PubMed
Summary
This summary is machine-generated.

Lower testosterone levels in men are linked to increased cardiovascular disease risk and mortality. Further research is needed to confirm if hormone therapy can reduce cardiovascular events in aging men.

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Gerontology

Background:

  • Age-related decline in sex hormones, particularly testosterone, is a growing concern in men's health.
  • Understanding the link between androgens and cardiovascular disease (CVD) is crucial for identifying treatable causes of ill-health.

Purpose of the Study:

  • To review recent research on the relationship between androgens and cardiovascular disease in men.
  • To discuss the implications of age-related changes in sex hormone levels for men's health.

Main Methods:

  • Review of recently published research on androgens and cardiovascular disease.
  • Analysis of observational studies and randomized trials.

Main Results:

  • Lower testosterone levels in middle-aged and older men are associated with insulin resistance, metabolic syndrome, diabetes, and increased CVD risk.
  • Reduced testosterone predicts cardiovascular events (stroke, transient ischemic attack) and is linked to higher cardiovascular and overall mortality.
  • Both high and low estradiol levels are associated with cardiovascular risk; testosterone supplementation showed protective effects against myocardial ischemia in men with coronary artery disease.

Conclusions:

  • Observational data consistently link lower testosterone to increased cardiovascular risk, atherosclerosis, and mortality in men.
  • The role of estradiol as a cardiovascular disease marker needs further investigation.
  • Larger randomized trials are required to determine if hormonal therapy can mitigate the cardiovascular disease burden in aging men.