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Related Experiment Video

Updated: Jun 15, 2026

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism
09:10

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Published on: January 12, 2019

In-vivo normothermic recirculation: an update.

Juan Carlos García-Valdecasas1, Constantino Fondevila

  • 1Unidad de Trasplante Hepático, Institut de Malalties Digestives y Metabolicas, Hospital Clínic, Barcelona, Villarroel, Barcelona, Spain. jcvalde@clinic.ub.es

Current Opinion in Organ Transplantation
|February 27, 2010
PubMed
Summary

Nonheart-beating donors (NHBD) increase liver transplants. Normothermic machine perfusion with recirculation shows promise for graft recovery and evaluation, improving transplant efficacy and safety.

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Area of Science:

  • Hepatology
  • Transplantation Surgery
  • Organ Donation

Background:

  • Liver transplantation activity is limited by donor organ availability.
  • Nonheart-beating donors (NHBD) offer a potential solution to increase the donor pool.
  • Strict criteria and advanced techniques have improved outcomes with NHBD grafts.

Purpose of the Study:

  • To evaluate the efficacy of normothermic recirculation and machine perfusion in improving liver graft quality from NHBD.
  • To assess the potential of NHBD to increase liver transplant numbers.
  • To determine the safety and tolerability of these techniques.

Main Methods:

  • Utilizing normothermic recirculation for liver grafts from NHBD (Type II).
  • Implementing normothermic machine perfusion post-procurement.

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An Open-Source Normothermic Perfusion System Designed for Research Scientists
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An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

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Last Updated: Jun 15, 2026

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism
09:10

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

Published on: January 12, 2019

An Open-Source Normothermic Perfusion System Designed for Research Scientists
11:23

An Open-Source Normothermic Perfusion System Designed for Research Scientists

Published on: July 18, 2025

  • Evaluating graft recovery from ischemic injury and assessing graft quality.

    • Main Results:

    • Normothermic recirculation in Type II NHBD yielded 66% graft and 73% patient survival.
    • Normothermic machine perfusion aids in recovering livers from warm ischemic injury.
    • This perfusion method allows for objective evaluation of potential donor liver grafts.

    Conclusions:

    • NHBD are crucial for increasing liver transplant numbers.
    • Normothermic recirculation is effective and well-tolerated for NHBD grafts.
    • Adding normothermic machine perfusion can significantly enhance the safety and efficacy of liver transplantation using NHBD.