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Susceptibility to bronchiolitis in infants

Alfin G Vicencio1

  • 1Children's Hospital at Montefiore and Albert Einstein College of Medicine, Bronx, New York, USA. dvicenci@montefiore.org

Current Opinion in Pediatrics
|February 27, 2010
PubMed

Insights

Respiratory syncytial virus (RSV) causes significant childhood bronchiolitis. Recent research advances our understanding of RSV infection susceptibility and interactions within the pediatric airway, paving the way for new treatments.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • Bronchiolitis is a heterogeneous respiratory disease in children.
  • Respiratory syncytial virus (RSV) is a primary cause of pediatric bronchiolitis.
  • Mechanisms of severe RSV infection susceptibility remain poorly understood.

Purpose of the Study:

  • To review recent advances in understanding RSV bronchiolitis.
  • To explore environmental and host risk factors for severe RSV infection.
  • To highlight new investigative techniques for studying RSV-pediatric airway interactions.

Main Methods:

  • Review of recent epidemiologic observations.
  • Analysis of novel in-vitro discoveries.
  • Examination of new investigative techniques.

Main Results:

  • Significant progress has been made in understanding RSV bronchiolitis.
  • Advances include insights into environmental and host risk factors.
  • New techniques are emerging to study RSV-airway interactions.

Conclusions:

  • RSV is a major global cause of pediatric morbidity and mortality.
  • Current investigations provide a foundation for future mechanistic studies.
  • Findings may lead to new preventive strategies and treatments for RSV bronchiolitis.
Abstract

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