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Related Experiment Video

Updated: Jun 15, 2026

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
10:35

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

Circulating nucleic acids as a new diagnostic tool.

Marketa Urbanova1, Jan Plzak, Hynek Strnad

  • 1Department of Otorhinolaryngology and Head and Neck Surgery, Institute of Postgraduate Medicine, Charles University, Prague, Czech Republic.

Cellular & Molecular Biology Letters
|February 27, 2010
PubMed
Summary
This summary is machine-generated.

Circulating nucleic acids offer non-invasive diagnostic potential for various disorders, including cancer and fetal abnormalities. Further large-scale studies are needed to integrate these promising techniques into routine clinical practice.

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Last Updated: Jun 15, 2026

A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction
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A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

Published on: April 5, 2018

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids
06:53

Detection and Monitoring of Tumor Associated Circulating DNA in Patient Biofluids

Published on: June 8, 2019

Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Clinical Diagnostics

Background:

  • The discovery of circulating nucleic acids (CNAs) in the 1940s.
  • CNAs are found in plasma and have diagnostic potential.
  • Non-invasive detection, monitoring, and screening of human disorders.

Purpose of the Study:

  • To review the applications of circulating nucleic acids in human health.
  • To highlight the potential of CNAs in early disease detection and monitoring.
  • To identify the need for further research for clinical implementation.

Main Methods:

  • Analysis of published studies on circulating nucleic acids.
  • Review of applications in oncology, prenatal diagnostics, transplant monitoring, and emergency medicine.
  • Synthesis of findings regarding diagnostic and prognostic value.

Main Results:

  • Circulating tumour markers aid in early cancer detection and prediction of tumor behavior.
  • Maternal plasma analysis detects fetal abnormalities and screens for pregnancy-associated disorders.
  • CNAs are useful in transplant monitoring, graft rejection assessment, and stratifying trauma/burn severity.

Conclusions:

  • Circulating nucleic acids show significant promise for non-invasive diagnostics across various medical fields.
  • Despite promising results, widespread clinical adoption requires further large-scale validation studies.
  • Standardization of technologies and broad patient cohort studies are essential for routine clinical practice.