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Peripheral arterial tonometry for risk stratification in men with coronary artery disease

Kevin S Heffernan1, Richard H Karas, Eshan A Patvardhan

  • 1The Vascular Function Study Group; Division of Cardiology, Tufts Medical Center, Boston, Massachusetts 02111, USA. kheffernan@tuftsmedicalcenter.org

Clinical Cardiology
|February 27, 2010
PubMed

Insights

Peripheral arterial tonometry (PAT) can identify high-risk patients with coronary artery disease (CAD). This noninvasive tool measures microvascular endothelial function, aiding in residual risk stratification for men with stable CAD.

Area of Science:

  • Cardiology
  • Vascular Biology
  • Biomarkers

Background:

  • Traditional risk factors inadequately predict coronary artery disease (CAD) risk.
  • A simple, noninvasive tool for identifying high-risk CAD patients in clinical settings is needed.

Purpose of the Study:

  • To test if peripheral arterial tonometry (PAT) is associated with residual cardiovascular risk in men with CAD.
  • To evaluate PAT as a tool for microvascular endothelial function assessment.

Main Methods:

  • Finger PAT measured pulse wave amplitude during reactive hyperemia (PWA-RH) in 42 men with stable CAD.
  • Plasma levels of high-sensitivity C-reactive protein (hs-CRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) were used for risk reclassification.

Main Results:

  • PWA-RH was significantly lower in high-risk (1.3 ± 0.04) versus moderate-risk (1.6 ± 0.07) and low-risk (2.0 ± 0.1) groups.
  • PWA-RH significantly predicted high-risk status in men with CAD via logistic regression.

Conclusions:

  • Peripheral microvascular endothelial function measurement using PAT can differentiate risk levels in men with stable CAD.
  • PAT may assist in residual risk stratification for high-risk individuals with well-controlled LDL-C.
Abstract

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