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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jun 15, 2026

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery
11:49

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

Published on: April 3, 2026

Neoadjuvant therapy for breast cancer.

Stephen V Liu1, Laleh Melstrom, Kathy Yao

  • 1Division of Medical Oncology, Department of Medicine, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.

Journal of Surgical Oncology
|February 27, 2010
PubMed
Summary

Neoadjuvant therapy for breast cancer has evolved to include chemotherapy, endocrine, and targeted treatments. It improves surgical options and outcomes for breast cancer patients, especially those seeking breast-conserving therapy (BCT).

Related Experiment Videos

Last Updated: Jun 15, 2026

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery
11:49

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

Published on: April 3, 2026

Area of Science:

  • Oncology
  • Breast Cancer Research
  • Neoadjuvant Therapy

Background:

  • Neoadjuvant therapy for breast cancer has significantly increased in complexity and application over recent decades.
  • Initially focused on systemic chemotherapy for advanced or inflammatory breast cancer, it now integrates chemotherapy, endocrine therapy, and targeted therapy.

Purpose of the Study:

  • To review the evolving role and benefits of neoadjuvant systemic therapy in breast cancer management.
  • To explore the implications of neoadjuvant therapy on breast-conserving therapy (BCT) options.
  • To discuss the timing of sentinel lymph node biopsy and the use of magnetic resonance imaging (MRI) for predicting treatment response.

Main Methods:

  • Literature review summarizing current practices and research in neoadjuvant breast cancer therapy.
  • Analysis of the impact of neoadjuvant systemic therapy on surgical outcomes and patient eligibility for BCT.
  • Evaluation of diagnostic tools like MRI for assessing treatment efficacy.

Main Results:

  • Neoadjuvant therapy is crucial for inoperable breast cancers and beneficial for operable cases aiming for BCT.
  • It can significantly alter surgical options, potentially enabling breast conservation.
  • The review highlights the importance of MRI in predicting treatment response.

Conclusions:

  • Neoadjuvant systemic therapy offers substantial benefits for breast cancer patients, enhancing surgical outcomes and BCT eligibility.
  • Optimizing the timing of interventions like sentinel node biopsy and utilizing predictive tools like MRI are key to successful neoadjuvant treatment strategies.