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Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

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Published on: June 20, 2018

Diverse interneuron populations have highly specific interconnectivity in the rat piriform cortex.

Cezar Gavrilovici¹, Sabrina D'Alfonso, Michael O Poulter

¹Molecular Brain Research Group, Department of Physiology and Pharmacology, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.

The Journal of Comparative Neurology

|February 27, 2010

Summary

This study maps the distribution and wiring of interneurons in the piriform cortex (PC). We found distinct patterns for parvalbumin (PV), calbindin (CB), and calretinin (CR) neurons, revealing complex innervation critical for olfactory processing and epilepsy research.

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Biocytin Recovery and 3D Reconstructions of Filled Hippocampal CA2 Interneurons

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Published on: November 20, 2018

Area of Science:

Neuroscience
Olfactory System Research
Cellular Neuroanatomy

Background:

The piriform cortex (PC) is crucial for olfactory memory and has high interconnectivity, potentially leading to seizures.
Distinct interneurons expressing calcium-binding proteins (CBPs) like parvalbumin (PV), calbindin (CB), and calretinin (CR) are present in the PC.
A comprehensive understanding of CBP interneuron distribution and innervation patterns in the PC is lacking.

Purpose of the Study:

To comprehensively analyze the localization and innervation patterns of distinct CBP-expressing interneurons within the piriform cortex.
To correlate the morphological characteristics of these interneurons with their synaptic targets.

Main Methods:

Immunohistochemical analysis of CBP (PV, CB, CR) expression in piriform cortex layers.
Morphological characterization of interneuron dendritic arborization.
Analysis of postsynaptic targets of specific CBP-positive nerve terminals.

Main Results:

CR-positive neurons were exclusively found in layer 1 of the PC.
PV and CB were coexpressed in layers 2-3, with most cells expressing both.
Distinct arborization patterns were observed: PV and PV/CB cells showed wide horizontal and vertical spread, CB cells had wide horizontal and restricted vertical spread, and CR cells had restricted horizontal and long vertical spread.
Specific innervation patterns were identified: PV(+) and PV/CB(+) terminals targeted perisomatic regions, CR(+) terminals targeted dendrites, and CB(+) terminals targeted both somata and dendrites.

Conclusions:

The piriform cortex exhibits complex and specific innervation patterns by CBP-defined interneuron subtypes.
These findings provide a detailed neuroanatomical basis for understanding PC function, plasticity, and its role in olfactory processing and neurological disorders like epilepsy.