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In vivo 19F MRI for Cell Tracking
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Published on: November 25, 2013

Quantitative 19F imaging using inductively coupled reference signal injection.

Donghoon Lee1, Kenneth Marro, Eric Shankland

  • 1Department of Radiology, University of Washington, Seattle, Washington 98195, USA. dhoonlee@u.washington.edu

Magnetic Resonance in Medicine
|February 27, 2010
PubMed
Summary
This summary is machine-generated.

This study introduces a synthetic voxel injection method for accurate metabolite quantification in Magnetic Resonance Imaging (MRI) and spectroscopy. This technique reliably measures metabolite content in real image voxels, even with changing conditions.

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Area of Science:

  • Medical Imaging
  • Magnetic Resonance Imaging
  • Spectroscopy

Background:

  • Previous work established synthetic free induction decay for metabolite quantification in MR spectroscopy.
  • This method utilized an inductively coupled injection coil for calibration.

Purpose of the Study:

  • To develop and validate a synthetic voxel injection method for quantifying metabolite content in Magnetic Resonance Imaging (MRI).
  • To assess the robustness of the quantification process under varying experimental conditions.

Main Methods:

  • Calibrated synthetic voxels were injected using an inductively coupled coil.
  • Images of sodium fluoride (NaF) and sodium chloride (NaCl) vials with varying concentrations were acquired.
  • Quantification was achieved by referencing metabolite content in real voxels to precalibrated synthetic voxels.

Main Results:

  • The synthetic voxel injection method successfully quantified metabolite content in real (19)F image voxels.
  • The quantification process demonstrated robustness and immunity to changes in coil loading, as shown with NaCl experiments.

Conclusions:

  • Synthetic voxel injection is a viable and robust method for metabolite quantification in MRI.
  • This technique enhances the accuracy and reliability of quantitative MRI and spectroscopy.