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NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
Polar Coordinates: Problem Solving01:27

Polar Coordinates: Problem Solving

Directional radiation patterns are central to antenna analysis, as they illustrate how signal strength varies with direction. These patterns are often modeled using polar plots, where the radial distance from the origin represents signal intensity at a given angle. A commonly used idealized form is the four-lobed rose curve, which captures the concept of directional beams in a simplified mathematical form.The four-lobed rose curve, described by r = cos⁡(2θ), features four symmetric lobes, each...
Gradient Fields01:27

Gradient Fields

A gradient field is a vector field derived from a scalar field. A scalar field assigns a single numerical value to every point in space, such as temperature, pressure, or electric potential. The gradient field describes how that value changes from point to point. It gives both the direction of the fastest increase and the rate of change in that direction.For a scalar field f(x, y), the gradient is written as\begin{equation*}\nabla f=\left\langle \jfrac{\partial f}{\partial x},\jfrac{\partial...
Space Curves01:25

Space Curves

A space curve describes the path followed by a particle moving through three-dimensional space. Unlike plane curves, which are confined to two coordinates, space curves require three coordinate functions. If t is a parameter, the position of the particle is represented by the vector function\begin{equation*}\mathbf{r}(t)=\langle x(t),y(t),z(t)\rangle,\end{equation*}where x(t), y(t), and z(t) are differentiable functions of t. As t varies over an interval, the endpoints of the position vectors...
Rectangular and Triangular Pulse Function01:19

Rectangular and Triangular Pulse Function

The unit rectangular pulse function is mathematically represented by a rectangular function centered at the origin with a height of one unit. This function is defined by two parameters: T, which specifies the center location of the pulse along the time axis, and τ, which determines the pulse duration.
For example, consider a rectangular pulse with a 5V amplitude, a 3-second duration, and centered at t=2 seconds. This pulse can be expressed using the rectangular function, written as,
Two-Dimensional (2D) NMR: Overview01:12

Two-Dimensional (2D) NMR: Overview

The 1D NMR spectrum of large and complex molecules like natural products has complicated splitting patterns and overlapping signals, which can be easily interpreted using 2-dimensional (2D) NMR. Unlike 1D NMR, 2D NMR has two frequency axes that provide the coupling information between the nucleus A and nucleus B in a molecule. The process from which 2D spectra are obtained has four steps.
The first step is the preparation period, during which nucleus A is excited with a radiofrequency pulse.

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Related Experiment Video

Updated: Jun 15, 2026

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
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3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

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A three-dimensional variable-density spiral spatial-spectral RF pulse with rotated gradients.

Weiran Deng1, V Andrew Stenger

  • 1Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813-2427, USA. weiran@hawaii.edu

Magnetic Resonance in Medicine
|February 27, 2010
PubMed
Summary

Periodically rotated variable-density spirals enhance spatial resolution in MRI without compromising frequency selectivity. This technique improves excitation resolution, crucial for applications like lipid imaging.

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Published on: September 26, 2016

Area of Science:

  • Magnetic Resonance Imaging (MRI)
  • Radiofrequency Pulse Design
  • Medical Physics

Background:

  • 3D spatial-spectral radiofrequency pulses with stack-of-spirals trajectories enable simultaneous spatial localization and spectral selection.
  • These pulses are valuable for reduced field-of-view applications requiring frequency specificity, such as lipid imaging.
  • Current limitations include fixed spiral trajectory lengths that restrict spatial excitation resolution.

Purpose of the Study:

  • To investigate the use of periodically rotated variable-density spirals for enhanced spatial excitation resolution.
  • To achieve higher resolution without altering the inherent frequency selectivity of the pulses.
  • To mitigate aliasing artifacts introduced by undersampling high spatial frequencies.

Main Methods:

  • Implementation of periodically rotated variable-density spiral trajectories.
  • Undersampling of high spatial frequencies to increase excitation resolution.
  • Periodic rotation to distribute aliasing across the frequency domain.
  • Validation through simulations, phantom studies, and in vivo imaging at 3 Tesla.

Main Results:

  • Demonstrated improvement in spatial excitation resolution from 6x6 to 8x8 matrix size in human leg muscle imaging.
  • Significant reduction in aliasing artifacts, ranging from 40-60%.
  • Maintained frequency selectivity for applications like lipid imaging.

Conclusions:

  • Periodically rotated variable-density spirals effectively increase spatial excitation resolution in 3D spatial-spectral MRI.
  • This method offers a solution to overcome limitations of fixed-length spiral trajectories.
  • The technique shows promise for advanced MRI applications requiring both high spatial resolution and spectral specificity.