Related Experiment Video
Updated: Jun 15, 2026
In Vivo Evaluation of Fracture Callus Development During Bone Healing in Mice Using an MRI-compatible Osteosynthesis Device for the Mouse Femur
Published on: November 14, 2017
Development of a signal-inducing bone cement for magnetic resonance imaging
Florian Wichlas1, Hermann J Bail, J Hermann Bail
1Center for Musculoskeletal Surgery, University Charité, Berlin, Germany. florian.wichlas@charite.de
Purpose:
To develop a signal-inducing bone cement for musculoskeletal procedures in magnetic resonance imaging (MRI).
Materials And Methods:
Acrylic resins were mixed with contrast agents (CAs) and water. We determined the ideal concentration of the components and assessed feasibility in cadaveric bones in an open high-field MR scanner. The contrast-to-noise ratio (CNR) in air and bone was evaluated and mechanical tests were achieved. We determined the amount of water that was not incorporated and measured the amount of CA released with photometric analysis. The cement was analyzed microscopically.
Results:
Preparation and application of the CA-water-cement compound was feasible and its differentiation in MRI was clear. The maximal CNR(air) had a value of 157.5 (SD 18.3) in an interventional fast T1W turbo-spin echo (TSE) sequence. The compressive strength decreased with the amount of water added. Although nearly 50% of the water added was not incorporated in the cement, the CNR was sufficient for cement detection. The threshold for systemic toxicity of delivered CA was not reached and the microscopic analysis showed water bubbles in the cement.
Conclusion:
A signal-inducing bone cement is feasible for the use in MRI.
