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Updated: Jun 15, 2026

Assays for the Degradation of Misfolded Proteins in Cells
Published on: August 28, 2016
Protein degradation, aggregation, and misfolding
Ana Maria Cuervo1, Esther S P Wong, Marta Martinez-Vicente
1Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA. amcuervo@aecom.yu.edu
Abstract:
The cellular surveillance systems guarantee proper removal of altered components from inside cells. Alterations of these systems in neurons have been proposed to be involved in the pathogenesis of different neurodegenerative disorders. In this review, we comment on the advances in our current understanding of how changes in the intracellular proteolytic systems, the main components of the cellular quality control system, contribute to neurodegeneration, with special emphasis on Parkinson's disease.
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