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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Asymmetric total synthesis of vindoline.

Daisuke Kato1, Yoshikazu Sasaki, Dale L Boger

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|March 2, 2010
PubMed
Summary

This study details a concise asymmetric total synthesis of (-)-vindoline using a tandem cycloaddition cascade. A chiral substituent controls stereochemistry, efficiently constructing the pentacyclic core and its functionality in one step.

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