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Updated: Jun 15, 2026
A Multiplex Serological Assay for the Detection of Antibody Responses to Arboviruses
Published on: November 4, 2025
Serological evidence of human hantavirus infections in Guinea, West Africa
Boris Klempa1, Lamine Koivogui, Oumar Sylla
1Institute of Virology, Helmut-Ruska-Haus, Charité Medical School, Berlin, and 2Institute of Virology, Philipps University Marburg, Marburg, Germany; 3Institute of Virology, Slovak Academy of Sciences, Bratislava, Slovakia; 4Viral Hemorrhagic Fever Project, University of Conakry, Conakry, Guinea.
Abstract:
We recently discovered a novel hantavirus, Sangassou virus, in Guinea, West Africa. Using enzyme-linked immunosorbent assays followed by confirmatory and serotyping assays, we retrospectively detected hantavirus antibodies in 3 (4.4%) of 68 patients with fever of unknown origin in Sangassou village, Forest Guinea. A population-based survey in Forest Guinea (n = 649) found the prevalence of hantavirus antibodies to be 1.2%. Specific neutralizing antibodies against Sangassou virus were demonstrated in serum samples from 2 patients and in 2 serum samples of the serosurvey. Our data allow us to conclude that hantavirus infections may be a significant unrecognized medical problem in at least this part of Africa.
