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Related Experiment Video

Updated: Jun 15, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
05:25

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Prostatic diseases in the senescence: structural and proliferative features.

Amanda C Hetzl1, Wagner J Favaro, Athanase Billis

  • 1Department of Anatomy, Institute of Biology, University of Campinas, SP, Brazil.

The Aging Male : the Official Journal of the International Society for the Study of the Aging Male
|March 2, 2010
PubMed
Summary

Aging (senescence) contributes to prostate diseases in men. This study reveals structural damage and altered cell growth in aging prostates, indicating increased proliferation is key to cancer development.

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Last Updated: Jun 15, 2026

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05:25

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Published on: August 14, 2019

Murine Prostate Micro-dissection and Surgical Castration
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How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases
13:18

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

Published on: September 20, 2016

Area of Science:

  • Urology
  • Gerontology
  • Pathology

Background:

  • Senescence is a key factor in male androgen ablation and prostate diseases.
  • The signaling mechanisms of prostatic lesions remain poorly understood.

Purpose of the Study:

  • To characterize structural, ultrastructural, and proliferative aspects of the peripheral prostate zone in elderly men.
  • To investigate these aspects in men with and without prostatic lesions and potential prostate cancer precursors.

Main Methods:

  • Analysis of 60 prostatic tissue samples from men aged 60-90 years.
  • Categorization into four groups: standard, benign prostatic hyperplasia, high-grade prostatic intraepithelial neoplasia, and prostatic carcinoma.
  • Inclusion of morphometrical, structural, ultrastructural, apoptosis, and proliferative analyses.

Main Results:

  • Observed morphological damage in prostatic stroma and secretory organelles.
  • Detected a disturbed proliferation/apoptosis rate in prostatic lesions, with a proliferative prevalence.
  • Identified an imbalanced stroma-epithelium interaction due to structural changes.

Conclusions:

  • Structural changes and altered proliferation/apoptosis rates are critical in elderly men's prostate health.
  • Imbalanced stroma-epithelium interaction is a detrimental feature linked to prostate carcinogenesis.
  • Findings highlight the role of senescence in prostate disease progression and cancer development.