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Updated: Jun 15, 2026

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
Published on: August 9, 2022
Patent arterial duct, bottle-meal, and fatal myocardial ischaemia
Simon Fluri1, Mladen Pavlovic, Bendicht P Wagner
1Department of Pediatrics, Pediatric Intensive Care Unit, University Hospital, Bern, Switzerland. simon.fluri@insel.ch
Abstract:
A patent arterial duct in pre-term neonates is frequent. Systemic complications consecutive to left-to-right shunting are well known but fatal myocardial ischaemia has not been described till now. The presented premature baby died from catecholamine refractory cardiogenic shock. Autoptic examination revealed acute ischaemic changes predominantly in the inner third of myocardium, speaking of coronary hypoperfusion due to a steal phenomenon secondary to the patent arterial duct.
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