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[Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency]

Christian Schwartz1, Valentin Le Douce, Thomas Cherrier

  • 1Inserm Unité 575 Physiopathologie du système nerveux central, Institut de virologie, Strasbourg, France. schwartz.christian@iutlpa-strasbg.fr

Medecine Sciences : M/S
|March 2, 2010
PubMed

The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus.

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