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Cortical dopamine D2/D3 receptors and verbal memory in man
Ville Lumme1, Mika M Hirvonen, Tuula Ilonen
1Turku PET Centre, Turku University Hospital, 20521 Turku, Finland.
Introduction:
It has been previously reported that hippocampal dopamine D2/D3 receptors are involved in the regulation of verbal memory and learning in healthy volunteers. We tested this hypothesis further and studied whether cortical dopamine D2/D3 receptor availability in vivo is associated with verbal memory as assessed with the revised Wechsler Memory Scale (WMS-R).
Methods:
Forty healthy Finnish subjects were evaluated according to the WMS-R and scanned with positron emission tomography (PET) and dopamine D2/D3 receptor radioligand [(11)C]FLB457 for the measurement of cortical D2/D3 receptor binding.
Results:
WMS-R verbal memory and learning parameters did not significantly correlate with D2/D3 receptor binding potential (BP(ND)) in the studied cortical regions.
Conclusions:
Our findings do not support a major role for cortical D2/D3 receptors in the regulation of verbal memory in healthy individuals.
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