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Related Experiment Video

Updated: Jun 15, 2026

A Chronic High-Intensity Interval Training and Diet-Induced Obesity Model to Maximize Exercise Effort and Induce Physiologic Changes in Rats

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Effect of exercise training on chronic inflammation.

Kristen M Beavers¹, Tina E Brinkley, Barbara J Nicklas

¹J. Paul Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|March 2, 2010

Summary

Regular physical activity may reduce chronic inflammation, a risk factor for disease and aging. While studies suggest exercise improves inflammatory markers, large trials are needed to confirm effects and optimal exercise levels.

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Published on: October 17, 2018

Area of Science:

Exercise Science
Immunology
Gerontology

Background:

Persistent sub-clinical inflammation is linked to chronic diseases and aging-related disability.
The inflammatory pathway presents a therapeutic target for lifestyle interventions.
Physical exercise is recognized for chronic disease risk reduction and improving inflammatory profiles.

Purpose of the Study:

To review evidence on the role of physical activity in reducing chronic inflammation.
To assess the impact of exercise on systemic inflammation markers.

Main Methods:

Review of large population-based cohort studies.
Analysis of data from small-scale intervention studies.
Evaluation of limited large randomized controlled trials on exercise and inflammation.

Main Results:

Cohort studies consistently show an inverse association between physical activity/fitness and systemic inflammation markers.
Small intervention studies suggest exercise training reduces inflammation.
Large randomized controlled trials yield inconclusive results.

Conclusions:

Evidence suggests physical exercise may reduce chronic inflammation.
Further research is required to determine the magnitude of exercise's effect and optimal parameters for clinical benefit.
Understanding exercise's impact on inflammation is crucial for disease and disability prevention.