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Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
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An introduction to clinical research in osteopathic medicine

Brian E Earley1, Helen Luce

  • 1Department of Family Medicine, University of Wisconsin School of Medicine and Public Health, 1100 Dela Plaine Court, Madison, WI 53715, USA. brian.earley@fammed.wisc.edu

Primary Care
|March 2, 2010
PubMed

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Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
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