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Updated: Jun 15, 2026

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
09:33

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Vascular risk factors, endothelial function, and carotid thickness in patients with migraine: relationship to

Sherifa A Hamed1, Enas A Hamed, Azza M Ezz Eldin

  • 1Department of Neurology, Assiut University Hospital, Egypt. hamed_sherifa@yahoo.com

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|March 2, 2010
PubMed

Insights

Migraine is linked to vascular issues, including endothelial dysfunction and increased carotid artery intima-media thickness. These findings suggest migraine may be a risk factor for atherosclerosis.

Area of Science:

  • Neurology
  • Vascular Medicine
  • Cardiology

Background:

  • Migraine is increasingly recognized for its association with vascular risk factors.
  • However, functional and structural vascular abnormalities in migraineurs require further investigation.

Purpose of the Study:

  • To evaluate vascular risk factors, endothelial function, and carotid artery intima-media thickness (CA-IMT) in individuals with migraine.
  • To determine the relationship between these markers and migraine characteristics.

Main Methods:

  • A preliminary study involving 63 adult migraineurs and 35 healthy controls.
  • Assessment of vascular risk factors (BMI, blood pressure, lipids, glucose, insulin), plasma endothelin-1 (ET-1), brachial artery flow-mediated dilation (FMD%), and CA-IMT.
  • Multivariate analysis to identify correlations between variables.

Main Results:

  • Migraineurs exhibited elevated systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, insulin, ET-1, and CA-IMT compared to controls.
  • FMD% was inversely correlated with SBP, DBP, glucose, and insulin.
  • CA-IMT showed correlations with BMI, SBP, total cholesterol, triglycerides, glucose, insulin, and FMD%.

Conclusions:

  • Migraine is associated with endothelial injury, impaired endothelial vasoreactivity, and increased CA-IMT.
  • These vascular abnormalities are linked to common vascular risk factors.
  • The findings suggest that migraine may represent a risk factor for the development of atherosclerosis.

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