Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Durability of efficacy, safety, and quality of life 5 years after valoctocogene roxaparvovec gene transfer for severe hemophilia A: final phase 3 GENEr8-1 trial results.

Research and practice in thrombosis and haemostasis·2026
Same author

Relationships between bleeding assessment tools (ISTH-BAT, Self-BAT) and quality of life in patients with bleeding symptoms.

Research and practice in thrombosis and haemostasis·2026
Same author

Rapid detection of fibrinolytic activation in postpartum hemorrhage and acute obstetric coagulopathy using a novel assay.

Blood advances·2025
Same author

Final Analysis of a Study of Etranacogene Dezaparvovec for Hemophilia B.

The New England journal of medicine·2025
Same author

When sickle cell trait is not just trait: risk of VTE.

Hematology. American Society of Hematology. Education Program·2025
Same author

Red cell physiologic stress results in lower quality transfusions: a randomized trial in adults with sickle cell disease.

Blood. Red cells & iron·2025

Related Experiment Video

Updated: May 4, 2026

Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry
09:39

Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry

Published on: March 17, 2015

22.9K

Analysis of tissue factor positive microparticles.

Nigel S Key1

  • 1Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, NC 27599, USA. Nigel_key@med.unc.edu

Thrombosis Research
|March 2, 2010
PubMed
Summary
This summary is machine-generated.

Clinical measurement of tissue factor (TF)-positive microparticles (MPs) is gaining interest due to their role in thrombus propagation. Current assays for MP-TF have limitations, and MP heterogeneity influences their function and clearance.

More Related Videos

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis
03:53

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis

Published on: December 29, 2023

1.4K
Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
10:08

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

1.8K

Related Experiment Videos

Last Updated: May 4, 2026

Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry
09:39

Techniques for the Analysis of Extracellular Vesicles Using Flow Cytometry

Published on: March 17, 2015

22.9K
Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis
03:53

Author Spotlight: High-Sensitivity Tissue Factor Activity Assay for Plasma Diagnosis

Published on: December 29, 2023

1.4K
Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
10:08

Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets

Published on: November 22, 2024

1.8K

Area of Science:

  • Biomedical research
  • Hematology
  • Clinical diagnostics

Background:

  • Tissue factor (TF)-positive microparticles (MPs) are implicated in thrombus propagation.
  • Clinical measurement of circulating TF-positive MPs is of significant interest.
  • TF-positive MPs may play a role in various disease states.

Purpose of the Study:

  • To review the current state of clinical measurement of TF-positive MPs.
  • To discuss the immunological and functional assays available for MP-TF.
  • To highlight the challenges and potential of MP-TF measurement.

Main Methods:

  • Review of existing immunological and functional assays for MP-TF.
  • Discussion of MP heterogeneity and its impact.
  • Analysis of the clinical relevance of TF-positive MPs.

Main Results:

  • Both immunological and functional assays for MP-TF exist, but neither is a definitive gold standard.
  • Heterogeneity of TF-bearing MPs, including phosphatidylserine co-expression, affects their procoagulant potential and clearance.
  • Further research is needed to establish reliable and standardized methods for MP-TF measurement.

Conclusions:

  • Standardized and validated assays are needed for reliable clinical measurement of TF-positive MPs.
  • Understanding MP heterogeneity is crucial for interpreting their clinical significance.
  • TF-positive MPs represent a promising area for clinical diagnostics and therapeutic targeting.